Mitochondria are present in all mammalian cells except matured red blood cells.
Mitochondria consist of several metabolic pathways for glucose, fatty acids, amino acids …

Pyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation that links
glycolysis-derived pyruvate with the TCA cycle. Although skeletal muscle is a significant site …

Carbohydrates and lipids integrate into a complex metabolic network that is essential to
maintain homeostasis. In insects, as in most metazoans, dietary carbohydrates are taken up …

Prostate cancer (PC) is the most commonly found malignancy among men globally. Many
genetic and epigenetic factors involving multiple cellular signaling networks are implicated …

Pancreatic β-cells exist in an incredibly dynamic microenvironment that impacts cell
metabolism, maturity, and function. Our research group previously showed that pancreatic β …

Interrupting a major pathway in intermediary metabolism leads to an accumulation of
substrates and upstream metabolites, downstream product de ciency, changes in feedback …

A common hallmark of cancer progression is a metabolic wiring which upregulates glucose
metabolism to support macromolecule biosynthesis and rapid proliferation; however, the …

It has become increasingly clear that mitochondria are active at different stages of
oncogenesis, heralding that targeting mitochondrial metabolism is a promising strategy for …

La mitochondrie est au coeur des réorientations métaboliques permettant aux cellules
cancéreuses de subvenir à leurs besoins énergétiques et métaboliques croissants. Les …

Hepatocellular carcinoma (HCC) accounted for around 4% of all cancer cases in 2020. This
number was expected to increase in the future, given the continuing poor prognosis …