Articular cartilage serves as a low-friction, load-bearing tissue without the support with blood
vessels, lymphatics and nerves, making its repair a big challenge. Transforming growth …

Homoeostasis depends on the close connection and intimate molecular exchange between
extracellular, intracellular and intercellular networks. Intercellular communication is largely …

Gap junction intercellular communication (GJIC) allows the transfer of material, message
and energy between cells, which influences cell behaviors including cell proliferation …

Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a
vital role in regulation of joint development, homeostasis, and diseases, but its role as a …

Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic
Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated …

Osteocytes are the main sensitive cells in bone remodeling due to their potent functional cell
processes from the mineralized bone matrix to the bone surface and the bone marrow …

The exquisite cartilage architecture maintains an orderly dynamic equilibrium as a result of
the interplay between chondrocyte functions and the unique extracellular matrix (ECM) …

Osteocytes are the main sensitive and responsive cells for mechanical stimuli in bone. The
connexin family enables them to communicate with each other via forming functional gap …

Purposes Gap junction intercellular communication (GJIC) is essential for articular cartilage
to respond appropriately to physical or biological stimuli and maintain homeostasis …

It is recognized that the interaction between cells and their physical microenvironment plays
a fundamental role in controlling cell behaviors and even in determining cell fate. Any …