[HTML][HTML] Gamma-aminobutyric acid Signaling in damage response, metabolism, and disease

K Kim, H Yoon - International Journal of Molecular Sciences, 2023 - mdpi.com
Gamma-aminobutyric acid (GABA) plays a crucial role in signal transduction and can
function as a neurotransmitter. Although many studies have been conducted on GABA in …

[HTML][HTML] The Molecular Heterogeneity of Store-Operated Ca2+ Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1/TRPC4 Channels in the Transition …

F Moccia, V Brunetti, A Perna, G Guerra… - International journal of …, 2023 - mdpi.com
Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

[HTML][HTML] Allyl Isothiocianate Induces Ca2+ Signals and Nitric Oxide Release by Inducing Reactive Oxygen Species Production in the Human Cerebrovascular …

R Berra-Romani, V Brunetti, G Pellavio, T Soda… - Cells, 2023 - mdpi.com
Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the
human brain both under basal conditions and in response to somatosensory stimulation. An …

[HTML][HTML] Intracellular Ca2+ signalling: unexpected new roles for the usual suspect

F Moccia, A Fiorio Pla, D Lim, F Lodola… - Frontiers in …, 2023 - frontiersin.org
Cytosolic Ca 2+ signals are organized in complex spatial and temporal patterns that
underlie their unique ability to regulate multiple cellular functions. Changes in intracellular …

[HTML][HTML] Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells

F Moccia, D Montagna - Cells, 2023 - mdpi.com
Moderate levels of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), fuel
tumor metastasis and invasion in a variety of cancer types. Conversely, excessive ROS …

[HTML][HTML] Cracking the Endothelial Calcium (Ca2+) Code: A Matter of Timing and Spacing

F Moccia, V Brunetti, T Soda, R Berra-Romani… - International Journal of …, 2023 - mdpi.com
A monolayer of endothelial cells lines the innermost surface of all blood vessels, thereby
coming into close contact with every region of the body and perceiving signals deriving from …

[HTML][HTML] Two Signaling Modes Are Better than One: Flux-Independent Signaling by Ionotropic Glutamate Receptors Is Coming of Age

V Brunetti, T Soda, R Berra-Romani, G De Sarro… - Biomedicines, 2024 - mdpi.com
Glutamate is the major excitatory neurotransmitter in the central nervous system.
Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs) …

Effects of dietary supplementation of different levels of gamma-aminobutyric acid on reproductive performance, glucose intolerance, and placental development of gilts

S Ma, J Li, H Ye, S Huang, Z Huang… - Journal of Animal …, 2024 - academic.oup.com
This study aimed to investigate the effects of dietary gamma-aminobutyric acid (GABA)
supplementation on reproductive performance, glucose intolerance, and placental …

[HTML][HTML] Identification of Differentially Expressed miRNAs in Porcine Adipose Tissues and Evaluation of Their Effects on Feed Efficiency

M Liao, Z Ren, Y Miao - Genes, 2022 - mdpi.com
Feed efficiency (FE) is a very important trait affecting the economic benefits of pig breeding
enterprises. Adipose tissue can modulate a variety of processes such as feed intake, energy …

Proton mechanisms of neurotransmission and calcium signalling for impulse initiation, development and propagation

G Molinari - 2023 - preprints.org
Protons are gaining increasing attention as neurotransmitters due to their extraordinary
abilities to rapidly transfer electrical charge, mobilize cellular calcium and modulate ion …