Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a
congenital blood disorder characterized by considerable phenotypic diversity. It comprises a …

Nitric oxide (NO), a vasodilator contributes to the vaso-occlusive crisis associated with the
sickle cell disease (SCD). Vascular nitric oxide helps in vasodilation, controlled platelet …

Background Children with acute and chronic illness undergo frequent, painful, and
distressing procedures. Objective This randomized controlled trial was used to evaluate the …

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …

Existing treatment for chronic pain in sickle cell disease (SCD) is opioid-dependent, which is
ineffective and carries risks. We conducted a scoping literature review to assess the size and …

Objectives We used the National Health Interview Survey (NHIS) data set to examine the
prevalence of comorbid medical conditions; explore barriers to accessing healthcare and …

Background Neuropathic pain (NP) has been previously explored in adolescents with sickle
cell disease (SCD). This study aims to describe the prevalence of NP in adolescents with …

This study compared neurological complications among a national sample of United States
children with or without sickle cell disease (SCD) and evaluated health status, healthcare …

Background Sickle cell disease (SCD) is an inherited autosomal recessive disorder
exhibiting a range of symptoms and acute and/or chronic complications that affect the quality …

Pain in Sickle Cell Disease (SCD) is a major comorbidity and unique with acute pain due to
recurrent and episodic vaso-occlusive crises as well as chronic pain, which can span an …