Lab on a chip devices for fertility: from proof-of-concept to clinical impact

R Nosrati - Lab on a Chip, 2022 - pubs.rsc.org
Microfluidics offers tremendous opportunities to understand the underlying biology of
fertilization at the single-cell level and improve infertility management, however, its true …

Sperm quality metrics were improved by a biomimetic microfluidic selection platform compared to swim-up methods

SA Vasilescu, L Ding, FY Parast, R Nosrati… - Microsystems & …, 2023 - nature.com
Sperm selection is an essential component of all assisted reproductive treatments (ARTs)
and is by far the most neglected step in the ART workflow in regard to technological …

High-DNA integrity sperm selection using rheotaxis and boundary following behavior in a microfluidic chip

S Zeaei, MZ Targhi, I Halvaei, R Nosrati - Lab on a Chip, 2023 - pubs.rsc.org
Rheotaxis, as one of the main natural guidance mechanisms in vivo, has been used in
microfluidics to separate motile sperm. However, the lack of DNA integrity assessment and …

Development of a novel cervix-inspired tortuous microfluidic system for efficient, high-quality sperm selection

E Dadkhah, MA Hajari, S Abdorahimzadeh… - Lab on a Chip, 2023 - pubs.rsc.org
Microfluidic systems have been extensively studied in recent years as potential alternatives
for problematic conventional methods of sperm selection. However, despite the widespread …

Selecting active matter according to motility in an acoustofluidic setup: self-propelled particles and sperm cells

VR Misko, L Baraban, D Makarov, T Huang, P Gelin… - Soft Matter, 2023 - pubs.rsc.org
Active systems–including sperm cells, living organisms like bacteria, fish, birds, or active soft
matter systems like synthetic “microswimmers”–are characterized by motility, ie, the ability to …

[PDF][PDF] The cooperative impact of flow and viscosity on sperm flagellar energetics in biomimetic environments

FY Parast, AS Gaikwad, R Prabhakar… - Cell Reports Physical …, 2023 - cell.com
Complex rheological properties of the female reproductive tract serve as a long-range
guidance mechanism for sperm. However, conventional microscopy methods and …

Faster sperm selected by rheotaxis leads to superior early embryonic development in vitro

M Yaghoobi, A Abdelhady, A Favakeh, P Xie… - Lab on a Chip, 2024 - pubs.rsc.org
To understand the impact of sperm speed as they swim against the flow on fertilization rates,
we created conditions similar to the female reproductive tract (FRT) on a microfluidic …

Viscous Loading Regulates the Flagellar Energetics of Human and Bull Sperm

F Yazdan Parast, S Veeraragavan, AS Gaikwad… - Small …, 2023 - Wiley Online Library
The viscoelastic properties of the female reproductive tract influence sperm swimming
behavior, but the exact role of these rheological changes in regulating sperm energetics …

Sperm motion in viscous environments with applications in microfluidics-based selection

S Xiao - 2023 - search.proquest.com
Male infertility is a major global concern and is defined by an ejaculate that's function is
hindered by insufficient sperm counts and/or low-quality sperm that obscure fertilization …

A Biomimetic Microfluidic Selection Platform Providing Improved Sperm Quality Metrics Compared to Swim-Up

ME Warkiani, S Vasilescu, L Ding, FY Parast, R Nosrati - 2022 - researchsquare.com
Sperm Selection is an essential component of all Assisted Reproductive Treatments (ART),
and is by far and large the most neglected step in the ART workflow when it comes to …