Purpose: Treatment of breast cancer has been increasingly successful in recent years with
the advent of HER2-receptor targeted treatment and endocrine treatment. However, the …

Human breast tumors are infiltrated by memory CD4+ T cells along with increased numbers
of regulatory T cells (Treg) and plasmacytoid dendritic cells (pDC) that facilitate immune …

Plasmacytoid dendritic cells (pDCs) play immunosuppressive roles in the tumor
microenvironment (TME). However, the molecular mechanisms underlying the recruitment …

Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

Signal transducers and activators of transcription (STATs) mediate essential signaling
pathways in different biological processes, including immune responses, hematopoiesis …

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer
patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of …

One of the most powerful and multifaceted cytokines produced by immune cells are type I
interferons (IFNs), the basal secretion of which contributes to the maintenance of immune …

Background: Studies have shown that the expression of histone deacetylases (HDACs) is
significantly related to the tumor microenvironment (TME) in gastric cancer. However, the …

Even though melanoma is considered to be one of the most immunogenic solid tumors,
handling its development remains a challenge. The basis for such escape from antitumor …

Glioblastoma (GBM) is the most common and fatal primary central nervous system
malignancy in adults with a median survival of less than 15 months. Surgery, radiation, and …