Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …

Nuclear factor, erythroid 2 like 2 (NFE2L2, NRF2) is a transcription factor that regulates
various antioxidant enzymes. It plays a vital physiological role in regulating oxidative stress …

Immune checkpoint blockade (ICB) is regarded as a promising strategy for cancer therapy.
The histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), has been implicated …

The SARS‐CoV‐2 infection cycle is a multistage process that relies on functional
interactions between the host and the pathogen. Here, we repurposed antiviral drugs …

Despite the rapid advancement in the introduction of new drugs for cancer therapy, the
frequent emergence of drug resistance leads to disease progression or tumor recurrence …

Malignant melanoma is the leading cause of death among cutaneous malignancies. While
its incidence is increasing, the most recent cancer statistics show a small but clear decrease …

Simple Summary Enhancer of zeste homolog 2 (EZH2) modifies the trimethylation of Lys-27
of histone 3, affecting downstream target genes' expression. It was reported that EZH2 is …

Despite the development of novel therapeutic approaches and improved clinical
management, survival from metastatic disease remains poor. Indeed, metastasis accounts …

Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The
majority of CRC deaths are caused by tumor metastasis, even following treatment. There is …