Sufficient oxygen is required to maintain normal cellular and physiological function, such as
a creature's development, breeding, and homeostasis. Lately, some researchers have …

Patients with advanced prostate cancer (PCa) frequently develop skeletal metastases that
are associated with fractures, disability, and increased mortality. Within the bone metastatic …

Maintenance of skeletal integrity requires the coordinated activity of multinucleated bone-
resorbing osteoclasts and bone-forming osteoblasts. Osteoclasts form resorption lacunae on …

Catalpol isolated from Rehmannia glutinosa is a potent antioxidant and investigated against
many disorders. This review appraises the key molecular pathways of catalpol against …

There is a complex interaction between titanium dental implants, bone, and the immune
system. Among them, specific immune cells, macrophages play a crucial role in the …

Various biomaterials have been evaluated to enhance bone formation in critical-sized bone
defects; however, the ideal scaffold is still missing. The objective of this study was to …

Background WNT974 is a small molecule inhibitor of Wnt signaling that specifically inhibits
porcupine O-acyltransferase. This phase Ib dose-escalation study evaluated the maximum …

Medulloblastoma (MB) is the most common malignant childhood tumor of the brain.
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …

Osteoblast differentiation is an important process in skeletal development and bone
remodelling. Serious bone diseases occur from any delay, defect, or imbalance in …

De novo limb regeneration after amputation is restricted in mammals to the distal digit tip.
Central to this regenerative process is the blastema, a heterogeneous population of lineage …