Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into
adipocytes and osteoblasts. Various external stimuli, including environmental contaminants …

Implant failure, which is commonly associated with failure of osseointegration and peri-
implant infection, is a severe complication of orthopedic surgery. In particular, the survival …

WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required
for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals …

Lately, there has been an increasing demand for materials that could improve tissue
regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need …

Osteoporosis is a chronical, systemic skeletal disorder characterized by an increase in bone
resorption, which leads to reduced bone density. The reduction in bone mineral density and …

Bone is a highly vascularized tissue that relies on a close spatial and temporal interaction
between blood vessels and bone cells. As a result, angiogenesis is critical for bone …

Tissue-engineered graft substitutes have shown great potential to treat large bone defects.
While we usually assume that therapeutic approaches developed for appendicular bone …

Bone health-targeting drug development strategies still largely rely on inferior 2D in vitro
screenings. We aimed at developing a scaffold-free progenitor cell-based 3D …

CRISPR/Cas9 is a revolutionary genome editing technology with the tremendous
advantages such as precisely targeting/shearing ability, low cost and convenient operation …

Successful regeneration of critical-size defects remains one of the significant challenges in
regenerative engineering. These large-scale bone defects are difficult to regenerate and are …