Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice

P García-García, R Reyes, D García-Sánchez… - Journal of …, 2022 - Springer
Osteoporosis (OP) is characterized by a loss in bone mass and mineral density. The
stimulation of the canonical Wnt/β-catenin pathway has been reported to promote bone …

In vivo investigation of 3D printed polycaprolactone/graphene electro-active bone scaffolds

PRL Nalesso, W Wang, Y Hou, L Bagne, AT Pereira… - Bioprinting, 2021 - Elsevier
Additive manufactured scaffolds are widely used as 3D support structures for tissue
engineering. This paper investigates the mechanisms behind bone regeneration due to the …

Crucial role of Lamin A/C in the migration and differentiation of MSCs in bone

N Alcorta-Sevillano, I Macías, CI Rodríguez, A Infante - Cells, 2020 - mdpi.com
Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA
gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into …

ADSC-based cell therapies for musculoskeletal disorders: a review of recent clinical trials

S Lee, DS Chae, BW Song, S Lim, SW Kim… - International Journal of …, 2021 - mdpi.com
Recently published clinical trials involving the use of adipose-derived stem cells (ADSCs)
indicated that approximately one-third of the studies were conducted on musculoskeletal …

[HTML][HTML] Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes

H Jin, N Jiang, W Xu, Z Zhang, Y Yang, J Zhang… - Biomedicine & …, 2022 - Elsevier
In this experimental study, we evaluated the protective effects and the safety of main
flavanones derived from Rhizoma Drynariae (Gusuibu) in vitro and in vivo. The MTT assay …

A Review on Pathophysiology, and Molecular Mechanisms of Bacterial Chondronecrosis and Osteomyelitis in Commercial Broilers

VSR Choppa, WK Kim - Biomolecules, 2023 - mdpi.com
Modern day broilers have a great genetic potential to gain heavy bodyweights with a huge
metabolic demand prior to their fully mature ages. Moreover, this made the broilers prone to …

Recent updates on Wnt signaling modulators: a patent review (2014-2020)

VG Goswami, BD Patel - Expert Opinion on Therapeutic Patents, 2021 - Taylor & Francis
Introduction: Wnt signaling is a signal transduction pathway that plays a vital role in
embryonic development and normal tissue preservation. Dysfunction of it gives rise to …

Effect of resveratrol and mesenchymal stem cell monotherapy and combined treatment in management of osteoporosis in ovariectomized rats: role of SIRT1/FOXO3a …

MM Elseweidy, SE El-Swefy, MA Shaheen… - Archives of Biochemistry …, 2021 - Elsevier
Osteoporosis is a skeletal disorder that is common in postmenopausal women. It is
characterized by deteriorated bone mass and microarchitecture. In this study, we aimed to …

[HTML][HTML] Craniofacial sutures: Signaling centres integrating mechanosensation, cell signaling, and cell differentiation

DM Roth, K Souter, D Graf - European Journal of Cell Biology, 2022 - Elsevier
Cranial sutures are dynamic structures in which stem cell biology, bone formation, and
mechanical forces interface, influencing the shape of the skull throughout development and …

Genetic profiling of human bone marrow and adipose tissue-derived mesenchymal stem cells reveals differences in osteogenic signaling mediated by graphene

AF MacDonald, RD Trotter, CD Griffin, AJ Bow… - Journal of …, 2021 - Springer
Background In the last decade, graphene surfaces have consistently supported osteoblast
development of stem cells, holding promise as a therapeutic implant for degenerative bone …