Craniofacial development comprises a complex process in humans in which failures or
disturbances frequently lead to congenital anomalies. Cleft lip with/without palate (CL/P) is a …

On the cellular level, osteoporosis (OP) is a result of imbalanced bone remodeling, in which
osteoclastic bone resorption outcompetes osteoblastic bone formation. Currently available …

Novel strategies employing mechano-transducing materials eliciting biological outcomes
have recently emerged for controlling cellular behaviour. Targeted cellular responses are …

Aortic valve stenosis (AVS) is a prevailing and life-threatening cardiovascular disease in
adults over 75 years of age. However, the molecular mechanisms governing the …

Aims Cell therapy utilizing mesenchymal stem cells (MSCs) from healthy donors (HE-MSCs)
is a promising strategy for treating osteoporotic bone defects. This study investigated the …

Ossifying fibromyxoid tumor (OFMT) is a soft tissue tumor frequently displaying gene fusions,
most of which affect the PHF1 gene. PHF1 encodes plant homeodomain finger protein 1 …

Steroid-induced osteonecrosis of femoral head (SONFH) is a common and serious
complication caused by long-term and/or excessive use of glucocorticoids (GCs). The …

Bone homeostasis is a dynamic, multicellular process that is required throughout life to
maintain bone integrity, prevent fracture, and respond to skeletal damage. WNT16 has been …

Aims Postmenopausal osteoporosis is one of the world's biggest yet unnoticed health
issues. After ovariectomy, declined estrogen level significantly contributes to the elevation of …

Extracellular signal-regulated kinases (ERKs) are evolutionarily ancient signal transducers
of the mitogen-activated protein kinase (MAPK) family that have long been linked to the …