The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical
transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) …

The skeletal system is essential for preserving body structure and facilitating mobility;
however, bone diseases frequently result in significant disabilities, necessitating the …

Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype
lacking effective targeted therapies, necessitating innovative treatment approaches. While …

Ethnomedicinal records have long mentioned the historical usage of Alchemilla vulgaris L.
in folk medicine, particularly for the treatment of gynecological issues. Building on this …

Background Osteosarcoma (OSA) presents a clinical challenge and has a low 5‐year
survival rate. Currently, the lack of advanced stratification models makes personalized …

In tissue formation and regeneration processes, cells often move collectively, maintaining
connections through intercellular adhesions. However, the specific roles of cell–substrate …

Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in
medicinal chemistry. They are considered privileged structures since they constitute several …

Background Recurrence and metastasis are the major obstacles affecting the therapeutic
efficacy and clinical outcomes for patients with esophageal carcinoma (ESCA). Secreted …

Doxorubicin (DOX) is an effective anticancer agent, yet its clinical utility is hampered by dose-
dependent cardiotoxicity. This study explores the cardioprotective potential of Marein (Mar) …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that modulates integrin and
growth factor signaling pathways and is implicated in cancer cell migration, proliferation, and …