The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition
ME Elsherbiny, DR Brocks - Drug metabolism reviews, 2011 - Taylor & Francis
As part of everyday life, people are exposed to polycyclic aromatic hydrocarbons (PAHs).
Sources of PAHs include cigarette smoke, ingestion of contaminated food and water or …
Sources of PAHs include cigarette smoke, ingestion of contaminated food and water or …
Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway
Amiodarone (AM) is the most effective antiarrhythmic agent currently available. However,
clinical application of AM is limited by its serious toxic adverse effects including optic …
clinical application of AM is limited by its serious toxic adverse effects including optic …
Regulation of macroautophagy in amiodarone‐induced pulmonary fibrosis
P Mahavadi, L Knudsen, S Venkatesan… - The Journal of …, 2015 - Wiley Online Library
Amiodarone (AD) is an iodinated benzofuran derivative, especially known for its
antiarrhythmic properties. It exerts serious side‐effects even in patients receiving low doses …
antiarrhythmic properties. It exerts serious side‐effects even in patients receiving low doses …
NL MIND-BEST: A web server for ligands and proteins discovery—Theoretic-experimental study of proteins of Giardia lamblia and new compounds active against …
H González-Díaz, F Prado-Prado… - Journal of theoretical …, 2011 - Elsevier
There are many protein ligands and/or drugs described with very different affinity to a large
number of target proteins or receptors. In this work, we selected Ligands or Drug-target pairs …
number of target proteins or receptors. In this work, we selected Ligands or Drug-target pairs …
Involvement of oxidative stress and impaired lysosomal degradation in amiodarone‐induced schwannopathy
N Niimi, H Yako, M Tsukamoto… - European Journal of …, 2016 - Wiley Online Library
Amiodarone hydrochloride (AMD), an anti‐arrhythmic agent, has been shown to cause
peripheral neuropathy; however, its pathogenesis remains unknown. We examined the toxic …
peripheral neuropathy; however, its pathogenesis remains unknown. We examined the toxic …
A rapid HPLC method for the simultaneous determination of amiodarone and its major metabolite in rat plasma and tissues: a useful tool for pharmacokinetic studies
M Rodrigues, G Alves, A Ferreira… - Journal of …, 2013 - academic.oup.com
A rapid and sensitive high-performance liquid chromatography (HPLC) method was
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …
Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress
J Lu, K Miyakawa, RA Roth, PE Ganey - toxicological sciences, 2013 - academic.oup.com
Amiodarone (AMD), a class III antiarrhythmic drug, causes idiosyncratic hepatotoxicity in
human patients. We demonstrated previously that tumor necrosis factor-alpha (TNF-α) plays …
human patients. We demonstrated previously that tumor necrosis factor-alpha (TNF-α) plays …
Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells
FC Roth, JE Mulder, JF Brien, T Takahashi… - Chemico-biological …, 2013 - Elsevier
The potent and efficacious anti-dysrhythmic agent amiodarone (AM) can cause potentially
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …
In vitro study on the pulmonary cytotoxicity of amiodarone
MT Alsamri, T Pramathan, AK Souid - Toxicology mechanisms and …, 2013 - Taylor & Francis
Context: Amiodarone (an iodinated benzofuran) is a Class III antiarrhythmic drug that
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …
胺碘酮通过诱发炎症细胞积聚导致肺毒性的实验研究
赵圣刚， 陈善浆， 江力勤 - 中华全科医学, 2014 - cqvip.com
目的本研究探讨长期胺碘酮不同剂量对大鼠肺脏的影响. 方法随机选择雄性SD 大鼠30 只,
随机分为对照组(NC, n= 10), 胺碘酮低剂量组[n= 10, 50mg/(kg· d), AM50], 胺碘酮高剂量组[n …
随机分为对照组(NC, n= 10), 胺碘酮低剂量组[n= 10, 50mg/(kg· d), AM50], 胺碘酮高剂量组[n …