Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs)
that regulate processes common to both natural cellular behaviours during embryogenesis …

Early life experience influences stress reactivity and mental health through effects on
cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and …

Background & Aims Chronic, excessive alcohol consumption leads to alcoholic liver disease
(ALD) characterized by steatosis, inflammation, and eventually cirrhosis. The hepatocyte …

Among the transcription factors that are conserved across phylogeny, the grainyhead family
holds vital roles in driving the epithelial cell fate. In Drosophila, the function of grainyhead …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial
development, epithelial morphogenesis, neural tube closure, and dorso-ventral patterning …

Cleft lip and palate are common birth defects resulting from failure of the facial processes to
fuse during development. The mammalian grainyhead-like (Grhl1-3) genes play key roles in …

Craniofacial development in vertebrates involves the coordinated growth, migration, and
fusion of several facial prominences during embryogenesis, processes governed by strict …

Mutations in the transcription factor gene grainyhead-like 2 (GRHL2) are associated with
progressive non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28) …

The highly-conserved Grainyhead-like (Grhl) transcription factors are critical regulators of
embryogenesis that regulate cellular survival, proliferation, migration and epithelial integrity …