Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …
[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
Association between early treatment with tocilizumab and mortality among critically ill patients with COVID-19
Importance Therapies that improve survival in critically ill patients with coronavirus disease
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …
Thrombosis, bleeding, and the observational effect of early therapeutic anticoagulation on survival in critically ill patients with COVID-19
Background: Hypercoagulability may be a key mechanism of death in patients with
coronavirus disease 2019 (COVID-19). Objective: To evaluate the incidence of venous …
coronavirus disease 2019 (COVID-19). Objective: To evaluate the incidence of venous …
Stopping renin-angiotensin system inhibitors in patients with advanced CKD and risk of adverse outcomes: a nationwide study
Background It is unknown whether stopping renin-angiotensin system (RAS) inhibitor
therapy in patients with advanced CKD affects outcomes. Methods We studied patients …
therapy in patients with advanced CKD affects outcomes. Methods We studied patients …
Chemoprevention of colorectal cancer
BW Katona, JM Weiss - Gastroenterology, 2020 - Elsevier
Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …
Association between renin-angiotensin system blockade discontinuation and all-cause mortality among persons with low estimated glomerular filtration rate
Importance It is uncertain whether and when angiotensin-converting enzyme inhibitor (ACE-
I) and angiotensin II receptor blocker (ARB) treatment should be discontinued in individuals …
I) and angiotensin II receptor blocker (ARB) treatment should be discontinued in individuals …
Reporting of observational studies explicitly aiming to emulate randomized trials: a systematic review
Importance Observational (nonexperimental) studies that aim to emulate a randomized trial
(ie, the target trial) are increasingly informing medical and policy decision-making, but it is …
(ie, the target trial) are increasingly informing medical and policy decision-making, but it is …
Effectiveness of molnupiravir and nirmatrelvir–ritonavir in hospitalized patients with COVID-19: a target trial emulation study
Background: Whether hospitalized patients benefit from COVID-19 oral antivirals is
uncertain. Objective: To examine the real-world effectiveness of molnupiravir and …
uncertain. Objective: To examine the real-world effectiveness of molnupiravir and …
Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease: nationwide cohort study
Objective To identify the optimal estimated glomerular filtration rate (eGFR) at which to
initiate dialysis in people with advanced chronic kidney disease. Design Nationwide …
initiate dialysis in people with advanced chronic kidney disease. Design Nationwide …