Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …

Ionic liquids are remarkable chemical compounds, which find applications in many areas of
modern science. Because of their highly tunable nature and exceptional properties, ionic …

Gliomas constitute about 80% of brain tumors and have a meager two-year survival rate.
The treatment options available are very few because of poor prognosis and a lack of …

Human neuroscience has made remarkable progress in understanding basic aspects of
functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the …

We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-
1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability …

Glioblastoma is a most intractable and high‐mortality malignancy because of its extremely
low drug accessibility resulting from the blood–brain barrier (BBB). Here, it is reported that …

In recent decades, research scientists, molecular biologists, and pharmacologists have
placed a strong emphasis on cutting-edge nanostructured materials technologies to …

Intrathecal delivery methods have been used for many decades to treat a broad range of
central nervous system disorders. A literature review demonstrated that …

In spite of a great improvement in medical health services and an increase in lifespan, we
have witnessed a skyrocket increase in the incidence of central nervous system (CNS) …

There are several routes of administration to the brain, including intraparenchymal,
intraventricular, and subarachnoid injections. The blood-brain barrier (BBB) impedes the …