Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …

Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in
developed countries and in the ageing population. It is strongly correlated to median age …

Mechanical forces are well known for modulating heart valve developmental programs. Yet,
it is still unclear how genetic programs and mechanosensation interact during heart valve …

Aims Tetrahydrobiopterin (BH4) is a critical determinant of the biological function of
endothelial nitric oxide synthase. The present study was to investigate the role of valvular …

Bicuspid aortic valve (BAV) is the most common congenital valvular defect and is associated
with ascending aortic dilation (AAD) in a quarter of patients. AAD has been ascribed both to …

Calcific aortic valve disease (CAVD) is highly prevalent and has no pharmaceutical
treatment. Surgical replacement of the aortic valve has proved effective in advanced disease …

Calcific aortic valve disease (CAVD) is the most prevalent human valve disease worldwide.
Multiple factors induce" irreversible" pathological changes in the aortic valve leaflets …

Aortic stenosis (AS) remains one of the most common forms of valve disease, with significant
impact on patient survival. The disease is characterized by left ventricular outflow obstruction …

Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in older
individuals, but there is a lack of drug treatment. The cellular biological mechanisms of …

Clinically serious congenital heart valve defects arise from improper growth and remodeling
of endocardial cushions into leaflets. Genetic mutations have been extensively studied but …