Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

Previous studies have reported substantial involvement of the noradrenergic system in
Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become …

Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD)
differ by world region, suggesting that there are potentially modifiable risk factors for …

Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …

Numerous studies have investigated the impacts of common types of chronic pain (CP) on
patients' cognitive function and observed that CP was associated with later dementia. More …

Background The noradrenergic neurons of locus coeruleus (LC) project to the spinal dorsal
horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its …

Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …

Background The role of microglia in Alzheimer's disease (AD) pathogenesis is becoming
increasingly important, as activation of these cell types likely contributes to both pathological …