Chronic pain in the elderly: mechanisms and perspectives
APA Dagnino, MM Campos - Frontiers in Human Neuroscience, 2022 - frontiersin.org
Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …
associated with coexisting psychological disorders, such as depression and anxiety …
Apoptosis and its therapeutic implications in neurodegenerative diseases
NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …
Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
Numerous studies have investigated the impacts of common types of chronic pain (CP) on
patients' cognitive function and observed that CP was associated with later dementia. More …
patients' cognitive function and observed that CP was associated with later dementia. More …
Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective
Sex or gender differences in the risk of Alzheimer's disease and related dementias (ADRD)
differ by world region, suggesting that there are potentially modifiable risk factors for …
differ by world region, suggesting that there are potentially modifiable risk factors for …
Cholinergic modulation of glial function during aging and chronic neuroinflammation
R Gamage, I Wagnon, I Rossetti, R Childs… - Frontiers in Cellular …, 2020 - frontiersin.org
Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson's disease
CEJ Doppler, MB Kinnerup, C Brune, E Farrher… - Brain, 2021 - academic.oup.com
Previous studies have reported substantial involvement of the noradrenergic system in
Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become …
Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become …
TRP channels role in pain associated with neurodegenerative diseases
M Duitama, V Vargas-López, Z Casas… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …
Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in …
J Li, Y Wei, J Zhou, H Zou, L Ma, C Liu, Z Xiao… - Journal of …, 2022 - Springer
Background The noradrenergic neurons of locus coeruleus (LC) project to the spinal dorsal
horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its …
horn (SDH), and release norepinephrine (NE) to inhibit pain transmission. However, its …
A brainstem to circadian system circuit links Tau pathology to sundowning-related disturbances in an Alzheimer's disease mouse model
AE Warfield, P Gupta, MM Ruhmann, QL Jeffs… - Nature …, 2023 - nature.com
Alzheimer's disease (AD) patients exhibit progressive disruption of entrained circadian
rhythms and an aberrant circadian input pathway may underlie such dysfunction. Here we …
rhythms and an aberrant circadian input pathway may underlie such dysfunction. Here we …
MicroRNAs as potential orchestrators of Alzheimer's disease-related pathologies: insights on current status and future possibilities
Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …