Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Influenza A and B virus infections are a major cause of respiratory disease in humans and
are responsible for substantial morbidity and mortality worldwide. Vaccination against …

Remarkable progress has been made in developing intramuscular vaccines against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, they are limited with …

Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory
B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper …

Antigen-specific tissue-resident memory T cells (Trms) and neutralizing IgA antibodies
provide the most effective protection of the lungs from viral infections. To induce those …

Tissue-resident memory T (TRM) cells are increasingly associated with the outcomes of
health and disease. TRM cells can mediate local immune protection against infections and …

Rapid reaction to microbes invading mucosal tissues is key to protect the host against
disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a severe acute
respiratory syndrome that is called COVID-19. Clinical manifestations of COVID-19 include …

Annually, seasonal influenza is responsible for millions of infections and hundreds of
thousands of deaths. The current method for managing influenza is vaccination using a …

Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently
prevent infectious diseases and are safe in animal models and humans. In this study, we …