After several decades of intensive efforts, safe injectable preparations capable of effectively
delivering O2 to tissues and removing CO2, ie, so-called blood substitutes, appear to be …

Hemoglobin (Hb, Mw: 64 500) and albumin (Mw: 66 500) are major protein components in
our circulatory system. On the basis of bioconjugate chemistry of these proteins, we have …

Concentration changes of nitric oxide (NO) were monitored using an NO-sensitive electrode
in phosphate-buffered saline (PBS) with either free oxyhemoglobin (oxyHb) or red blood …

A new method for labeling preformed liposomes with technetium-99m (99m Tc) has been
developed which is simple to perform and stable in vivo. Previous 99m Tc-liposome labels …

In this study, we investigated the size distribution, encapsulation efficiency, and oxygen
affinity of liposome‐encapsulated tetrameric hemoglobin (LEHb) dispersions and correlated …

Liposome-encapsulated hemoglobin (LEH) is an erythrocyte substitute that is a potential
resuscitative fluid for the in vivo delivery of oxygen. We have noninvasively imaged …

In this review the current status of what commonly are termed “blood substitutes” is
discussed. The term blood substitute is a misnomer because the formulations under …

This is the first book that provides a comprehensive review of the entire area of artificial cells.
The author, a pioneer of the field, invented the first artificial cells some 50 years ago and has …

Biodegradable polymer membrane nanocapsules containing hemoglobin have been
prepared with phase separation and polymer precipitation methods. We have used different …

The most common and widely transplanted tissue world wide is blood, which in 2000
resulted in the transfusion of 12.5 million units of blood in the US alone [Goodnough LT …