Intra-pancreatic fat deposition: bringing hidden fat to the fore
Abstract Development of advanced modalities for detection of fat within the pancreas has
transformed understanding of the role of intra-pancreatic fat deposition (IPFD) in health and …
transformed understanding of the role of intra-pancreatic fat deposition (IPFD) in health and …
The immune landscape of human pancreatic ductal carcinoma: key players, clinical implications, and challenges
M Muller, V Haghnejad, M Schaefer, G Gauchotte… - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
and deadliest cancer worldwide, with an overall survival (OS) rate, all stages combined, of …
and deadliest cancer worldwide, with an overall survival (OS) rate, all stages combined, of …
Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen
Y Ogawa, Y Masugi, T Abe, K Yamazaki, A Ueno… - Clinical Cancer …, 2021 - AACR
Purpose: Cancer-associated fibroblasts have emerged to be highly heterogenous and can
play multifaceted roles in dictating pancreatic ductal adenocarcinoma (PDAC) progression …
play multifaceted roles in dictating pancreatic ductal adenocarcinoma (PDAC) progression …
[HTML][HTML] Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance
M Capula, M Perán, G Xu, V Donati, D Yee… - Drug Resistance …, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest incidence/death ratios
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
The potential roles of exosomes in pancreatic cancer initiation and metastasis
W Sun, Y Ren, Z Lu, X Zhao - Molecular cancer, 2020 - Springer
Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year
survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of …
survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of …
Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator …
Background Previous studies have revealed the role of dysregulated urokinase
plasminogen activator (encoded by PLAU) expression and activity in several pathways …
plasminogen activator (encoded by PLAU) expression and activity in several pathways …
[HTML][HTML] Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer
The tumor microenvironment consists of diverse, complex etiological factors. The matrix
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …
[HTML][HTML] Differential contribution of pancreatic fibroblast subsets to the pancreatic cancer stroma
Background & Aims Although the healthy pancreas consists mostly of epithelial cells,
pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia …
pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia …
The desmoplastic stroma of pancreatic cancer: multilayered levels of heterogeneity, clinical significance, and therapeutic opportunities
Y Masugi - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic cancer is a highly malignant disease with treatment resistance
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …
Targeting HGF/c-MET axis in pancreatic cancer
Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …
disease that is associated with early metastases. It is characterized by dense and …