Strategies for the nuclear delivery of metal complexes to cancer cells

M Huynh, R Vinck, B Gibert, G Gasser - Advanced Materials, 2024 - Wiley Online Library
The nucleus is an essential organelle for the function of cells. It holds most of the genetic
material and plays a crucial role in the regulation of cell growth and proliferation. Since …

Nucleic-acid therapeutics: basic principles and recent applications

JB Opalinska, AM Gewirtz - Nature Reviews Drug Discovery, 2002 - nature.com
The sequencing of the human genome and the elucidation of many molecular pathways that
are important in disease have provided unprecedented opportunities for the development of …

[HTML][HTML] Three's a crowd–stabilisation, structure, and applications of DNA triplexes

M Dalla Pozza, A Abdullrahman, CJ Cardin… - Chemical …, 2022 - pubs.rsc.org
DNA is a strikingly flexible molecule and can form a variety of secondary structures,
including the triple helix, which is the subject of this review. The DNA triplex may be formed …

[HTML][HTML] Programmable genome editing tools and their regulation for efficient genome engineering

TK Guha, A Wai, G Hausner - Computational and structural biotechnology …, 2017 - Elsevier
Targeted genome editing has become a powerful genetic tool for studying gene function or
for modifying genomes by correcting defective genes or introducing genes. A variety of …

[HTML][HTML] Emerging therapies for Charcot-Marie-Tooth inherited neuropathies

M Stavrou, I Sargiannidou, E Georgiou… - International Journal of …, 2021 - mdpi.com
Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …

[HTML][HTML] A bouquet of DNA structures: Emerging diversity

M Kaushik, S Kaushik, K Roy, A Singh… - … and biophysics reports, 2016 - Elsevier
Structural polymorphism of DNA has constantly been evolving from the time of illustration of
the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA …

Charcot–Marie–Tooth neuropathies: current gene therapy advances and the route toward translation

M Stavrou, A Kagiava, I Sargiannidou… - Journal of the …, 2023 - Wiley Online Library
Abstract Charcot–Marie–Tooth (CMT) neuropathies are a group of genetically and
phenotypically heterogeneous disorders that predominantly affect the peripheral nervous …

[HTML][HTML] Feline coronavirus antivirals: a review

M Delaplace, H Huet, A Gambino, S Le Poder - Pathogens, 2021 - mdpi.com
Feline coronaviruses (FCoV) are common viral pathogens of cats. They usually induce
asymptomatic infections but some FCoV strains, named Feline Infectious Peritonitis Viruses …

Triplex‐forming oligonucleotide target sequences in the human genome

JR Goñi, X de la Cruz, M Orozco - Nucleic acids research, 2004 - academic.oup.com
The existence of sequences in the human genome which can be a target for triplex
formation, and accordingly are candidates for anti‐gene therapies, has been studied by …

[HTML][HTML] Fluorescent probes for nucleic acid visualization in fixed and live cells

AS Boutorine, DS Novopashina, OA Krasheninina… - Molecules, 2013 - mdpi.com
This review analyses the literature concerning non-fluorescent and fluorescent probes for
nucleic acid imaging in fixed and living cells from the point of view of their suitability for …