Potassium channels (KChs) are the most diverse ion channels, in part due to extensive
combinatorial assembly of a large number of principal and auxiliary subunits into an …

Abstract Since Hodgkin and Huxley discovered the potassium current that underlies the
falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated …

Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …

Most spiking neurons are divided into functional compartments: a dendritic input region, a
soma, a site of action potential initiation, an axon trunk and its collaterals for propagation of …

Exposure to drugs of abuse, such as cocaine, leads to plastic changes in the activity of brain
circuits, and a prevailing view is that these changes play a part in drug addiction. Notably …

Unipolar brush cells (UBC) are small, glutamatergic neurons residing in the granular layer of
the cerebellar cortex and the granule cell domain of the cochlear nuclear complex. Recent …

Sea anemone venom is a known source of interesting bioactive compounds, including
peptide toxins which are invaluable tools for studying structure and function of voltage-gated …

Cancer is the second leading cause of death worldwide and is a major global health burden.
Significant improvements in survival have been achieved, due in part to advances in …

Neurons are highly polarized cells with apparent functional and morphological differences
between dendrites and axon. A critical determinant for the molecular and functional identity …

The incubation phenomenon, cue-induced drug craving progressively increasing over
prolonged withdrawal, accounts for persistent relapse, leading to a dilemma in the treatment …