Early brain activity: translations between bedside and laboratory
Neural activity is both a driver of brain development and a readout of developmental
processes. Changes in neuronal activity are therefore both the cause and consequence of …
processes. Changes in neuronal activity are therefore both the cause and consequence of …
[HTML][HTML] Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2
Coronavirus disease (COVID-19) is caused by a new strain of coronavirus, the severe acute
respiratory syndrome coronavirus 2 or SARS-CoV-2. At the time of writing, SARS-CoV-2 has …
respiratory syndrome coronavirus 2 or SARS-CoV-2. At the time of writing, SARS-CoV-2 has …
Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry
Despite the rising prevalence of methadone treatment in pregnant women with opioid use
disorder, the effects of methadone on neurobehavioral development remain unclear. We …
disorder, the effects of methadone on neurobehavioral development remain unclear. We …
[HTML][HTML] Effects of prenatal opioid exposure on functional networks in infancy
Prenatal opioid exposure has been linked to altered neurodevelopment and visual problems
such as strabismus and nystagmus. The neural substrate underlying these alterations is …
such as strabismus and nystagmus. The neural substrate underlying these alterations is …
Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae
afflicting adolescents exposed to opioids in the womb. A translationally relevant and …
afflicting adolescents exposed to opioids in the womb. A translationally relevant and …
Prenatal morphine exposure increases cardiovascular disease risk and programs neurogenic hypertension in the adult offspring
N Ahmed, A Kassis, J Malone, J Yang, E Zamzami… - …, 2023 - Am Heart Assoc
Background: The opioid overdose and opioid use disorder epidemics are concomitant with
increased metabolic and CVD risk. Although opioid use disorder causes adverse pregnancy …
increased metabolic and CVD risk. Although opioid use disorder causes adverse pregnancy …
Environmental enrichment mitigates the long-lasting sequelae of perinatal fentanyl exposure in mice
The opioid epidemic is a rapidly evolving societal issue driven, in part, by a surge in
synthetic opioid use. A rise in fentanyl use among pregnant women has led to a 40-fold …
synthetic opioid use. A rise in fentanyl use among pregnant women has led to a 40-fold …
[HTML][HTML] Unique pharmacology, brain dysfunction, and therapeutic advancements for fentanyl misuse and abuse
Y Han, L Cao, K Yuan, J Shi, W Yan, L Lu - Neuroscience Bulletin, 2022 - Springer
Fentanyl is a fully synthetic opioid with analgesic and anesthetic properties. It has become a
primary driver of the deadliest opioid crisis in the United States and elsewhere …
primary driver of the deadliest opioid crisis in the United States and elsewhere …
Prenatal opioid exposure enhances responsiveness to future drug reward and alters sensitivity to pain: a review of preclinical models and contributing mechanisms
The opioid crisis has resulted in an unprecedented number of neonates born with prenatal
opioid exposure (POE); however, the long-term effects of POE on offspring behavior and …
opioid exposure (POE); however, the long-term effects of POE on offspring behavior and …
[HTML][HTML] In utero methadone exposure permanently alters anatomical and functional connectivity: A preclinical evaluation
EM Chin, Y Kitase, NK Madurai, S Robinson… - Frontiers in …, 2023 - frontiersin.org
The opioid epidemic is an ongoing public health crisis, and children born following prenatal
opioid exposure (POE) have increased risk of long-term cognitive and behavioral sequelae …
opioid exposure (POE) have increased risk of long-term cognitive and behavioral sequelae …