Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …

Nature endows life with a wide variety of sophisticated, synergistic, and highly functional
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

The double-helix structure of DNA, in which complementary strands reversibly hybridize to
each other, not only explains how genetic information is stored and replicated, but also has …

Large differences between the DPP responses of ss-and dsDNAs (Figure 4B) suggest that
the double-helical structure of the dsDNA is not significantly disturbed at the DME surface …

Two aspects of low-resolution macromolecular crystal structure analysis are considered:(i)
the use of reference structures and structural units for provision of structural prior information …

Synthetic genetics is a subdiscipline of synthetic biology that aims to develop artificial
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …

Dimethyl sulfoxide (DMSO) is a small molecule with polar, aprotic and amphiphilic
properties. It serves as a solvent for many polar and nonpolar molecules and continues to be …

The ruthenium complex [Ru (phen) 2 (dppz)] 2+(where phen is phenanthroline and dppz
dipyridophenazine is known as a 'light switch'complex because its luminescence in solution …

Last generation of force-fields are raising expectations on the quality of molecular dynamics
(MD) simulations of DNA, as well as to the belief that theoretical models can substitute …