Regulation of Conidiogenesis in Aspergillus flavus

HJ Cho, SH Son, W Chen, YE Son, I Lee, JH Yu… - Cells, 2022 - mdpi.com
Aspergillus flavus is a representative fungal species in the Aspergillus section Flavi and has
been used as a model system to gain insights into fungal development and toxin production …

Developmental regulators in Aspergillus fumigatus

HS Park, JH Yu - Journal of Microbiology, 2016 - Springer
The filamentous fungus Aspergillus fumigatus is the most prevalent airborne fungal
pathogen causing severe and usually fatal invasive aspergillosis in immunocompromised …

New insights of transcriptional regulator AflR in Aspergillus flavus physiology

P Wang, J Xu, PK Chang, Z Liu, Q Kong - Microbiology Spectrum, 2022 - Am Soc Microbiol
Aspergillus flavus aflR, a gene encoding a Zn (II) 2Cys6 DNA-binding domain, is an
important transcriptional regulator of the aflatoxin biosynthesis gene cluster. Our previous …

Negative regulation and developmental competence in Aspergillus

MK Lee, NJ Kwon, IS Lee, S Jung, SC Kim, JH Yu - Scientific reports, 2016 - nature.com
Asexual development (conidiation) in the filamentous fungus Aspergillus nidulans is
governed by orchestrated gene expression. The three key negative regulators of conidiation …

Systematic dissection of the evolutionarily conserved WetA developmental regulator across a genus of filamentous fungi

MY Wu, ME Mead, MK Lee, EM Ostrem Loss, SC Kim… - MBio, 2018 - Am Soc Microbiol
Asexual sporulation is fundamental to the ecology and lifestyle of filamentous fungi and can
facilitate both plant and human infection. In Aspergillus, the production of asexual spores is …

An LaeA-and BrlA-dependent cellular network governs tissue-specific secondary metabolism in the human pathogen Aspergillus fumigatus

AL Lind, FY Lim, AA Soukup, NP Keller, A Rokas - Msphere, 2018 - Am Soc Microbiol
Biosynthesis of many ecologically important secondary metabolites (SMs) in filamentous
fungi is controlled by several global transcriptional regulators, like the chromatin modifier …

Fungal resilience and host–pathogen interactions: future perspectives and opportunities

AJP Brown - Parasite Immunology, 2023 - Wiley Online Library
We are constantly exposed to the threat of fungal infection. The outcome—clearance,
commensalism or infection—depends largely on the ability of our innate immune defences …

WetA bridges cellular and chemical development in Aspergillus flavus

MY Wu, ME Mead, SC Kim, A Rokas, JH Yu - PLoS One, 2017 - journals.plos.org
Bridging cellular reproduction and survival is essential for all life forms. Aspergillus fungi
primarily reproduce by forming asexual spores called conidia, whose formation and …

Functional Characterization of the GNAT Family Histone Acetyltransferase Elp3 and GcnE in Aspergillus fumigatus

YH Choi, SH Park, SS Kim, MW Lee, JH Yu… - International Journal of …, 2023 - mdpi.com
Post-translational modifications of chromatin structure by histone acetyltransferase (HATs)
play a pivotal role in the regulation of gene expression and diverse biological processes …

Characterization of gprK Encoding a Putative Hybrid G-Protein-Coupled Receptor in Aspergillus fumigatus

MG Jung, SS Kim, JH Yu, KS Shin - PLoS One, 2016 - journals.plos.org
The G-protein-coupled receptor (GPCR) family represents the largest and most varied
collection of membrane embedded proteins that are sensitized by ligand binding and …