Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
Tau-targeting therapies for Alzheimer disease
EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in
Alzheimer's disease and other primary tauopathies. One therapeutic strategy may be to …
Alzheimer's disease and other primary tauopathies. One therapeutic strategy may be to …
Tau pathology and neurodegeneration
MG Spillantini, M Goedert - The Lancet Neurology, 2013 - thelancet.com
The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and
filamentous tau protein is at the centre of many human neurodegenerative diseases …
filamentous tau protein is at the centre of many human neurodegenerative diseases …
Therapeutics of Alzheimer's disease: Past, present and future
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
Synaptic tau seeding precedes tau pathology in human Alzheimer's disease brain
Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles
(NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid …
(NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid …
A walk through tau therapeutic strategies
S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …
and related human tauopathies. There is a growing body of evidence indicating that …
Tau in Alzheimer's disease: mechanisms and therapeutic strategies
Y Gao, L Tan, JT Yu, L Tan - Current Alzheimer Research, 2018 - ingentaconnect.com
Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …
[HTML][HTML] Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
K Yanamandra, N Kfoury, H Jiang, TE Mahan, S Ma… - Neuron, 2013 - cell.com
Tau aggregation occurs in neurodegenerative diseases including Alzheimer's disease and
many other disorders collectively termed tauopathies. trans-cellular propagation of tau …
many other disorders collectively termed tauopathies. trans-cellular propagation of tau …
Tau-based therapies in neurodegeneration: opportunities and challenges
C Li, J Götz - Nature Reviews Drug Discovery, 2017 - nature.com
Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …