Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

Modulation of immune cell trafficking across the blood-brain barrier has not only introduced
a therapeutic avenue for multiple sclerosis (MS) but also represents an example of reverse …

Background Chronic active lesions (CAL) in multiple sclerosis (MS) have been observed
even in patients taking high-efficacy disease-modifying therapy, including B-cell depletion …

Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease,
relatively little is known about the precise nature of the immune dysregulation underlying the …

Background and objectives Immune responses in the central nervous system (CNS) are
highly compartmentalized and cerebrospinal fluid (CSF) in particular often reflects CNS …

Fungal infection or proliferation in our body is capable of initiation of strong inflammation
and immune responses that result in different consequences, including infection-trigged …

From deciphering infection and disease mechanisms to identifying novel biomarkers and
personalizing treatments, the characteristics of individual cells can provide significant …

The anti-CD20 monoclonal antibody ocrelizumab reduces disability progression in primary
progressive multiple sclerosis. CD20 is a prototypical B-cell marker; however …

Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA
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Tissue-resident macrophages play an important role in the local maintenance of
homeostasis and immune surveillance. In the central nervous system (CNS), brain …