Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential
risk factors enables clinicians to identify patients who are more likely to develop bipolar …

Hikikomori, a severe form of social withdrawal, has long been observed in Japan mainly
among youth and adolescents since around the 1970s, and has been especially highlighted …

The immune and inflammatory system is involved in the etiology of mood disorders.
Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and …

Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Objectives There is evidence that the gut microbiota plays a major role in the pathogenesis
of diseases of the central nervous system through the gut–brain axis. The aim of the present …

BackgroundA reliable biomarker signature for bipolar disorder sensitive to illness phase
would be of considerable clinical benefit. Among circulating blood-derived markers there …

In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …

Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in
bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the …

To characterize neuronal mitochondrial abnormalities in major depressive disorder (MDD),
functional mitochondrial proteins (MPs) extracted from enriched plasma neuron-derived …