Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation
tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific …

Limited bronchoalveolar lavage (BAL) as an extension of fiberoptic bronchoscopy has
permitted the recovery of airway-alveolar space cells and soluble substances in the …

Transforming growth factor-β (TGF-β) signaling plays an important regulatory role during
lung fibrogenesis. Smad3 was identified in the pathway for transducing TGF-β signals from …

There is a rapid onset of organizing alveolitis/fibrosis at 120–140 d after whole lung
irradiation of C57BL/6J mice. To test the hypothesis that circulating cells of bone marrow …

A histologic feature of usual interstitial pneumonia is the presence of fibroblastic foci. As
some patients with usual interstitial pneumonia and an underlying collagen vascular …

Based on studies by our group and others, we hypothesized that IL-7 may possess
antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have …

Abstract Changes in macrophage phenotype have been implicated in apoptotic cell-
mediated immune modulation via induction of peroxisome proliferator-activated receptor-γ …

The individual susceptibility to pulmonary fibrosis (PF) remains a mystery, suggesting a role
for genetic predisposition. The pathogenesis of PF involves a multitude of factors mediating …

The current study deals with the effect of a dietary flavanoid quercetin on fibrotic lung tissue
in rats. Bleomycin was administered by single intratracheal instillation to Wistar rats to …

Purpose: To examine and compare the molecular and cellular processes leading to
radiation fibrosis and pneumonitis in C57BL/6J and C3H/HeN mice. Methods and Materials …