Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

N Ghane, MH Beigi, S Labbaf… - Journal of Materials …, 2020 - pubs.rsc.org
Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal
functionality, directly affecting the quality of the patient's life. Due to the central nervous …

Methods for behavioral testing of spinal cord injured rats

J Šedý, L Urdzíková, P Jendelová, E Syková - … & Biobehavioral Reviews, 2008 - Elsevier
Behavioral outcome in rats with spinal cord injury (SCI) is the most important factor for
evaluating the extent of injury and treatment efficacy. For this purpose, a number of …

[HTML][HTML] Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats

X Wang, X Li, X Zuo, Z Liang, T Ding, K Li, Y Ma… - Journal of …, 2021 - Springer
Background Neurotoxic microglia and astrocytes begin to activate and participate in
pathological processes after spinal cord injury (SCI), subsequently causing severe …

[HTML][HTML] Growth differentiation factor 15 regulates oxidative stress-dependent ferroptosis post spinal cord injury by stabilizing the p62-Keap1-Nrf2 signaling pathway

M Xia, Q Zhang, Y Zhang, R Li, T Zhao… - Frontiers in Aging …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous
system (CNS) that causes irreversible damage to the nervous tissue. The consequent …

Drug-loaded zwitterion-based nanomotors for the treatment of spinal cord injury

T Bao, N Li, H Chen, Z Zhao, J Fan, Y Tao… - … Applied Materials & …, 2023 - ACS Publications
Spinal cord injury (SCI) treatment requires a nanosystem for drug delivery that can
effectively penetrate the blood–spinal cord barrier (BSCB). Herein, we designed poly (2 …

[HTML][HTML] Photobiomodulation attenuates neurotoxic polarization of macrophages by inhibiting the notch1-HIF-1α/NF-κB signalling pathway in mice with spinal cord …

Y Ma, P Li, C Ju, X Zuo, X Li, T Ding, Z Liang… - Frontiers in …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a catastrophic disease with a complex pathogenesis that includes
inflammation, oxidative stress, and glial scar formation. Macrophages are the main …

[HTML][HTML] Photobiomodulation promotes repair following spinal cord injury by regulating the transformation of A1/A2 reactive astrocytes

X Wang, Z Zhang, Z Zhu, Z Liang, X Zuo, C Ju… - Frontiers in …, 2021 - frontiersin.org
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive
phenotypes according to their different functions: neurotoxic (A1) astrocytes and …

[HTML][HTML] Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury

F Jiang, M Xia, Y Zhang, J Chang, J Cao… - Frontiers in …, 2022 - frontiersin.org
Background Neuroinflammation following spinal cord injury (SCI) results in prolonged
neurological damage and locomotor dysfunction. Polarization of microglia is vital to …

[HTML][HTML] Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury

FQ Kong, SJ Zhao, P Sun, H Liu, J Jie, T Xu… - Journal of …, 2020 - Springer
Background A sustained inflammatory response following spinal cord injury (SCI)
contributes to neuronal damage, inhibiting functional recovery. Macrophages, the major …

[HTML][HTML] Experimental spinal cord injury and behavioral tests in laboratory rats

RU Ahmed, M Alam, YP Zheng - Heliyon, 2019 - cell.com
Traumatic spinal cord injury (SCI) results in some serious neurophysiological consequences
that alter healthy body functions and devastate the quality of living of individuals. To find a …