Design of hydrogel-based scaffolds for the treatment of spinal cord injuries
N Ghane, MH Beigi, S Labbaf… - Journal of Materials …, 2020 - pubs.rsc.org
Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal
functionality, directly affecting the quality of the patient's life. Due to the central nervous …
functionality, directly affecting the quality of the patient's life. Due to the central nervous …
Methods for behavioral testing of spinal cord injured rats
J Šedý, L Urdzíková, P Jendelová, E Syková - … & Biobehavioral Reviews, 2008 - Elsevier
Behavioral outcome in rats with spinal cord injury (SCI) is the most important factor for
evaluating the extent of injury and treatment efficacy. For this purpose, a number of …
evaluating the extent of injury and treatment efficacy. For this purpose, a number of …
[HTML][HTML] Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats
X Wang, X Li, X Zuo, Z Liang, T Ding, K Li, Y Ma… - Journal of …, 2021 - Springer
Background Neurotoxic microglia and astrocytes begin to activate and participate in
pathological processes after spinal cord injury (SCI), subsequently causing severe …
pathological processes after spinal cord injury (SCI), subsequently causing severe …
[HTML][HTML] Growth differentiation factor 15 regulates oxidative stress-dependent ferroptosis post spinal cord injury by stabilizing the p62-Keap1-Nrf2 signaling pathway
M Xia, Q Zhang, Y Zhang, R Li, T Zhao… - Frontiers in Aging …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous
system (CNS) that causes irreversible damage to the nervous tissue. The consequent …
system (CNS) that causes irreversible damage to the nervous tissue. The consequent …
Drug-loaded zwitterion-based nanomotors for the treatment of spinal cord injury
T Bao, N Li, H Chen, Z Zhao, J Fan, Y Tao… - … Applied Materials & …, 2023 - ACS Publications
Spinal cord injury (SCI) treatment requires a nanosystem for drug delivery that can
effectively penetrate the blood–spinal cord barrier (BSCB). Herein, we designed poly (2 …
effectively penetrate the blood–spinal cord barrier (BSCB). Herein, we designed poly (2 …
[HTML][HTML] Photobiomodulation attenuates neurotoxic polarization of macrophages by inhibiting the notch1-HIF-1α/NF-κB signalling pathway in mice with spinal cord …
Y Ma, P Li, C Ju, X Zuo, X Li, T Ding, Z Liang… - Frontiers in …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a catastrophic disease with a complex pathogenesis that includes
inflammation, oxidative stress, and glial scar formation. Macrophages are the main …
inflammation, oxidative stress, and glial scar formation. Macrophages are the main …
[HTML][HTML] Photobiomodulation promotes repair following spinal cord injury by regulating the transformation of A1/A2 reactive astrocytes
X Wang, Z Zhang, Z Zhu, Z Liang, X Zuo, C Ju… - Frontiers in …, 2021 - frontiersin.org
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive
phenotypes according to their different functions: neurotoxic (A1) astrocytes and …
phenotypes according to their different functions: neurotoxic (A1) astrocytes and …
[HTML][HTML] Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury
F Jiang, M Xia, Y Zhang, J Chang, J Cao… - Frontiers in …, 2022 - frontiersin.org
Background Neuroinflammation following spinal cord injury (SCI) results in prolonged
neurological damage and locomotor dysfunction. Polarization of microglia is vital to …
neurological damage and locomotor dysfunction. Polarization of microglia is vital to …
[HTML][HTML] Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury
FQ Kong, SJ Zhao, P Sun, H Liu, J Jie, T Xu… - Journal of …, 2020 - Springer
Background A sustained inflammatory response following spinal cord injury (SCI)
contributes to neuronal damage, inhibiting functional recovery. Macrophages, the major …
contributes to neuronal damage, inhibiting functional recovery. Macrophages, the major …
[HTML][HTML] Experimental spinal cord injury and behavioral tests in laboratory rats
Traumatic spinal cord injury (SCI) results in some serious neurophysiological consequences
that alter healthy body functions and devastate the quality of living of individuals. To find a …
that alter healthy body functions and devastate the quality of living of individuals. To find a …