Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

The central nervous system (CNS) comprises the brain, spinal cord, optic nerves and retina,
and contains post-mitotic, delicate cells. As the rigid coverings of the CNS render swelling …

Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …

Epstein–Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-
reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T …

The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …

Helminths have evolved to become experts at subverting immune surveillance. Through
potent and persistent immune tempering, helminths can remain undetected in human …

Microglia, the macrophages of the central nervous system parenchyma, have in the normal
healthy brain a distinct phenotype induced by molecules expressed on or secreted by …

The Many Roles of Chemokines and Chemokine Receptors in Inflammation | NEJM Skip to
main content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare …

The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …