Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …

Protease-targeted chimeras (PROTACs) are a new technology that is receiving much
attention in the treatment of diseases. The mechanism is to inhibit protein function by …

Aims Prostate cancer is one of the most frequent causes of cancer death in men worldwide,
and novel drugs for prostate cancer therapies are still being developed. Palmitic acid is a …

Covering: 2006 to mid-2010 Marine-derived fungi continue to produce structurally unique
secondary metabolites, a considerable number of which display promising biological and …

Microtubules have long been considered an ideal target for anticancer drugs because of the
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …

Stilbenes are a small family of plant secondary metabolites derived from the
phenylpropanoid pathway, and produced in a number of unrelated plant species. These …

Noscapine is an antitumor alkaloid from opium poppy that binds tubulin, arrests metaphase,
and induces apoptosis in dividing human cells. Elucidation of the biosynthetic pathway will …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Covering: July 2007 to June 2010. Previous review: Nat. Prod. Rep., 2009, 26, 382–445 A
great number of structurally diverse natural products containing five-membered heterocyclic …

Cytoskeleton plays a significant role in the shape change, migration, movement, adhesion,
cytokinesis, and phagocytosis of tumor cells. In clinical practice, some anti-cancer drugs …