Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …

Frontotemporal dementia (FTD) is the second most common form of dementia. It affects the
frontal and temporal lobes of the brain and has a highly heterogeneous clinical …

The cytoplasmic accumulation of the nuclear protein transactive response DNA-binding
protein 43 kDa (TDP-43) has been linked to the progression of amyotrophic lateral sclerosis …

Hematopoietic stem cell transplantation can deliver therapeutic proteins to the central
nervous system (CNS) through transplant-derived microglia-like cells. However, current …

Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently
no disease-modifying treatment options available. Mutations in GRN are one of the most …

Background Alterations in progranulin (PGRN) expression are associated with multiple
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …

The morbidity of frontotemporal dementia (FTD), one of the most prevalent dementias
praccox, is second to Alzheimer disease (AD). It is different with AD that FTD has a rapider …

Heterozygous loss-of-function mutations in the progranulin gene (GRN) are a major cause of
frontotemporal dementia due to progranulin haploinsufficiency; complete deficiency of …

Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders that are
characterized by pathology predominantly localized to the frontal and temporal lobes …

Frontotemporal dementia (FTD) is a leading cause of early-onset dementia and has a
significant socioeconomic burden due to difficulties in diagnosis and delay to diagnosis. FTD …