DNA methylation profiles in cancer diagnosis and therapeutics

Y Pan, G Liu, F Zhou, B Su, Y Li - Clinical and experimental medicine, 2018 - Springer
Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Mechanistic insight into toxicity of phthalates, the involved receptors, and the role of Nrf2, NF-κB, and PI3K/AKT signaling pathways

H Mohammadi, S Ashari - Environmental Science and Pollution Research, 2021 - Springer
The wide use of phthalates, as phthalates are used in the manufacturing of not only plastics
but also many others goods, has become a main concern in the current century because of …

Toxicity of dibutyl phthalate to pakchoi (Brassica campestris L.): evaluation through different levels of biological organization

X Yao, J Zhang, C Wang, Q Wang, X Li, D Zhang… - Science of the Total …, 2022 - Elsevier
Dibutyl phthalate (DBP) is a typical persistent organic pollutant with a high load in the
agricultural soils of vegetable crops. Currently, studies on the toxicity of DBP in vegetable …

[HTML][HTML] Adult exposure to di-n-butyl phthalate (DBP) induces persistent effects on testicular cell markers and testosterone biosynthesis in mice

L Källsten, R Almamoun, P Pierozan… - International Journal of …, 2022 - mdpi.com
Studies indicate that phthalates are endocrine disruptors affecting reproductive health. One
of the most commonly used phthalates, di-n-butyl phthalate (DBP), has been linked with …

Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: a pilot study

M Tian, L Liu, J Zhang, Q Huang, H Shen - Chemosphere, 2019 - Elsevier
Accumulating evidence indicates that phthalate exposures may affect human semen quality.
Epigenetic modifications such as DNA methylation might be linked chemical exposure and …

Marked for life: epigenetic effects of endocrine disrupting chemicals

MN Jacobs, EL Marczylo… - Annual Review of …, 2017 - annualreviews.org
The presence of human-made chemical contaminants in the environment has increased
rapidly during the past 70 years. Harmful effects of such contaminants were first reported in …

[HTML][HTML] A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: proof of concept for phthalates and reproductive effects

KA Baken, N Lambrechts, S Remy, V Mustieles… - Environmental …, 2019 - Elsevier
Human biomonitoring measures the concentrations of environmental chemicals or their
metabolites in body fluids or tissues. Complementing exposure biomarkers with …

[HTML][HTML] Water and soil pollution as determinant of water and food quality/contamination and its impact on male fertility

A Di Nisio, C Foresta - Reproductive biology and endocrinology, 2019 - Springer
Over the past two decades, public health has focused on the identification of environmental
chemical factors that are able to adversely affect hormonal function, known as endocrine …

[HTML][HTML] Cytotoxicity, morphological and ultrastructural effects induced by the neonicotinoid pesticide, imidacloprid, using a rat Leydig cell line (LC-540)

MIA Ibrahim, GCH Ferreira, EA Venter… - Environmental Toxicology …, 2023 - Elsevier
Imidacloprid is a systemic neonicotinoid insecticide widely used to combat agricultural pests
and flea infestations in dogs and cats. Despite its low toxicity to mammals, imidacloprid is …

Interference of dibutylphthalate on human prostate cell viability

M Di Lorenzo, M Forte, S Valiante, V Laforgia… - Ecotoxicology and …, 2018 - Elsevier
Dibutylphthalate (DBP) is an environmental pollutant widely used as plasticizer in a variety
of industrial applications worldwide. This agent can be found in personal-care products …