Discrepancy between perceptions and acceptance of clinical decision support Systems: implementation of artificial intelligence for vancomycin dosing

X Liu, EF Barreto, Y Dong, C Liu, X Gao… - BMC Medical Informatics …, 2023 - Springer
Background Artificial intelligence (AI) tools are more effective if accepted by clinicians. We
developed an AI-based clinical decision support system (CDSS) to facilitate vancomycin …

Bayesian method application: Integrating mathematical modeling into clinical pharmacy through vancomycin therapeutic monitoring

A Chen, A Gupta, DH Do… - Pharmacology research & …, 2022 - Wiley Online Library
The most recent consensus guidelines for dosing and monitoring vancomycin
recommended the use of area‐under‐the‐curve with Bayesian estimation for therapeutic …

Antibiotic optimization in the intensive care unit

BD Lizza, N Raush, ST Micek - Seminars in Respiratory and …, 2022 - thieme-connect.com
Effective antimicrobial therapy remains paramount to successful treatment of patients with
critical illness, such as pneumonia and sepsis. Unfortunately, critically ill patients often …

Efficacy and safety of vancomycin loading doses in critically ill patients with methicillin-resistant Staphylococcus aureus infection

AH Flannery, KL Wallace, CN Rhudy… - Therapeutic …, 2021 - journals.sagepub.com
Background: While vancomycin loading doses may facilitate earlier pharmacokinetic–
pharmacodynamic target attainment, the impact of loading doses on clinical outcomes …

First‐Dose Vancomycin Pharmacokinetics Versus Empiric Dosing on Area‐Under‐the‐Curve Target Attainment in Critically Ill Patients

AH Flannery, NL Delozier, SA Effoe… - … : The Journal of …, 2020 - Wiley Online Library
background Early attainment of target area under the curve (AUC) to minimum inhibitory
concentration (MIC) ratios have been associated with clinical success, as well as lower …

Decreased Kidney Function Explains Higher Vancomycin Exposure in Older Adults

AE Edwina, E Dreesen, M Gijsen, HC van den Hout… - Drugs & Aging, 2024 - Springer
Introduction Older adults face a higher risk of vancomycin-related toxicity given their (patho)-
physiological changes, making early management of supratherapeutic exposure crucial …

Individualized vancomycin dosing with therapeutic drug monitoring and pharmacokinetic consultation service: a large-scale retrospective observational study

SM Kim, HS Lee, NY Hwang, K Kim… - Drug Design …, 2021 - Taylor & Francis
Background To date, outcome data with a large sample size and data regarding the clinical
outcomes of pharmacokinetic-guided (PK) dosing of vancomycin are limited. Aim We …

Review and evaluation of vancomycin dosing guidelines for obese individuals

S Wong, SE Reuter, GRD Jones… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Vancomycin dosing decisions are informed by factors such as body weight and
renal function. It is important to understand the impact of obesity on vancomycin …

Impact of Limiting Vancomycin Loading Doses in Patients With Methicillin-resistant Staphylococcus aureus Infections After Hospital Protocol Revision

AR Raley, ML Brown, M Frawley, RA Oster… - Hospital …, 2024 - journals.sagepub.com
Background: Vancomycin loading doses are commonly used to quickly attain target serum
concentrations; however, data supporting their effect on clinical patient outcomes is limited …

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응준, 현승, 형두, 수연 - Laboratory Medicine, 2022 - synapse.koreamed.org
Lab Med Online Laboratory Medicine Online Lab Med Online 2093-6338 Korean Society for
Laboratory Medicine 10.47429/lmo.2022.12.4.285 lmo-12-4-285 원저 임상화학 Comparison of …