Exercise metabolism and adaptation in skeletal muscle

JAB Smith, KA Murach, KA Dyar… - Nature Reviews Molecular …, 2023 - nature.com
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Skeletal muscle memory

AP Sharples, DC Turner - American Journal of Physiology …, 2023 - journals.physiology.org
Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …

Epigenetic and “redoxogenetic” adaptation to physical exercise

Z Radak, L Pan, L Zhou, S Mozaffaritabar, Y Gu… - Free Radical Biology …, 2023 - Elsevier
Exercise-induced adaptation is achieved by altering the epigenetic landscape of the entire
genome leading to the expression of genes involved in various processes including …

Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures

VD Nair, H Pincas, GR Smith, E Zaslavsky, Y Ge… - Cell Genomics, 2024 - cell.com
Regular exercise has many physical and brain health benefits, yet the molecular
mechanisms mediating exercise effects across tissues remain poorly understood. Here we …

Different resistance exercise loading paradigms similarly affect skeletal muscle gene expression patterns of myostatin-related targets and mTORC1 signaling markers

MC McIntosh, CL Sexton, JS Godwin, BA Ruple… - Cells, 2023 - mdpi.com
Although transcriptome profiling has been used in several resistance training studies, the
associated analytical approaches seldom provide in-depth information on individual genes …

Myofiber hypertrophy adaptations following 6 weeks of low-load resistance training with blood flow restriction in untrained males and females

TM Reece, JS Godwin, MJ Strube… - Journal of Applied …, 2023 - journals.physiology.org
The effects of low-load resistance training with blood flow restriction (BFR) on hypertrophy of
type I/II myofibers remains unclear, especially in females. The purpose of the present study …

[HTML][HTML] Exercise couples mitochondrial function with skeletal muscle fiber type via ROS-mediated epigenetic modification

J Li, Z Zhang, H Bo, Y Zhang - Free Radical Biology and Medicine, 2024 - Elsevier
Skeletal muscle is a heterogeneous tissue composed of different types of muscle fibers,
demonstrating substantial plasticity. Physiological or pathological stimuli can induce …

Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise

PP Gorski, DC Turner, J Iraki… - American Journal …, 2023 - journals.physiology.org
We aimed to investigate the human skeletal muscle (SkM) DNA methylome after exercise in
low-carbohydrate (CHO) energy-balance (with high-fat) conditions compared with exercise …

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation

ML Mattingly, BA Ruple, CL Sexton, JS Godwin… - Frontiers in …, 2023 - frontiersin.org
Although several reports have hypothesized that exercise may increase skeletal muscle
protein lactylation, empirical evidence in humans is lacking. Thus, we adopted a multi …