[HTML][HTML] Poor birth outcomes in malaria in pregnancy: recent insights into mechanisms and prevention approaches
Pregnant women in malaria-endemic regions are susceptible to malaria in pregnancy, which
has adverse consequences on birth outcomes, including having small for gestational age …
has adverse consequences on birth outcomes, including having small for gestational age …
Molecular approaches to determine the multiplicity of Plasmodium infections
Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the
number of genetically distinct parasite strains co-infecting a single host, which is an …
number of genetically distinct parasite strains co-infecting a single host, which is an …
PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study
SB Sirima, L Richert, A Chêne, AT Konate… - The Lancet Infectious …, 2020 - thelancet.com
Background PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy …
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy …
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA
R Ma, T Lian, R Huang, JP Renn, JD Petersen… - Nature …, 2021 - nature.com
Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
[HTML][HTML] Progress and insights toward an effective placental malaria vaccine
B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …
malaria is progressively acquired during childhood and adults are usually protected against …
Placental malaria
Abstract Purpose of Review Placental malaria is the primary mechanism through which
malaria in pregnancy causes adverse perinatal outcomes. This review summarizes recent …
malaria in pregnancy causes adverse perinatal outcomes. This review summarizes recent …
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
R Ma, ND Salinas, S Orr-Gonzalez… - PLoS …, 2024 - journals.plos.org
Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …
Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing
Background Deep sequencing of targeted genomic regions is becoming a common tool for
understanding the dynamics and complexity of Plasmodium infections, but its lower limit of …
understanding the dynamics and complexity of Plasmodium infections, but its lower limit of …
The pattern of neonatal admissions and mortality at a regional and district hospital in the Upper West Region of Ghana; a cross sectional study
EMA Tette, ET Nartey, BD Nuertey, EA Azusong… - PloS one, 2020 - journals.plos.org
Background High global neonatal deaths have triggered efforts to improve facility-based
care. However, the outcomes achievable at different levels of care are unclear. This study …
care. However, the outcomes achievable at different levels of care are unclear. This study …
Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development
Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum
parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite …
parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite …