Exercise metabolism and adaptation in skeletal muscle

JAB Smith, KA Murach, KA Dyar… - Nature Reviews Molecular …, 2023 - nature.com
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

[HTML][HTML] The muscle fiber profiles, mitochondrial content, and enzyme activities of the exceptionally well-trained arm and leg muscles of elite cross-country skiers

N Ørtenblad, J Nielsen, R Boushel, K Söderlund… - Frontiers in …, 2018 - frontiersin.org
As one of the most physically demanding sports in the Olympic Games, cross-country skiing
poses considerable challenges with respect to both force generation and endurance during …

Pathophysiology of lipid droplets in neuroglia

T Smolič, R Zorec, N Vardjan - Antioxidants, 2021 - mdpi.com
In recent years, increasing evidence regarding the functional importance of lipid droplets
(LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged …

Exercising your fat (metabolism) into shape: a muscle-centred view

A Gemmink, P Schrauwen, MKC Hesselink - Diabetologia, 2020 - Springer
Fatty acids are an important energy source during exercise. Training status and substrate
availability are determinants of the relative and absolute contribution of fatty acids and …

Lipid droplet motility and organelle contacts

MD Kilwein, MA Welte - Contact, 2019 - journals.sagepub.com
Lipid droplets (LDs) are fat storage organelles integral to energy homeostasis and a wide
range of cellular processes. LDs physically and functionally interact with many partner …

[PDF][PDF] Exercise induces tissue-specific adaptations to enhance cardiometabolic health

SP Ashcroft, B Stocks, B Egan, JR Zierath - Cell Metabolism, 2023 - cell.com
The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause
mortality is decreased in individuals who meet the current recommendations for physical …

Skeletal muscle lipid droplets and the athlete's paradox

X Li, Z Li, M Zhao, Y Nie, P Liu, Y Zhu, X Zhang - Cells, 2019 - mdpi.com
The lipid droplet (LD) is an organelle enveloped by a monolayer phospholipid membrane
with a core of neutral lipids, which is conserved from bacteria to humans. The available …

Intramuscular lipid utilization during exercise: a systematic review, meta-analysis, and meta-regression

JR Stokie, G Abbott, KF Howlett… - Journal of Applied …, 2023 - journals.physiology.org
Intramuscular lipid (IMCL) utilization during exercise was controversial as numerous studies
did not observe a decline in IMCL content post-exercise when assessed in muscle biopsies …

Acute exercise increases the contact between lipid droplets and mitochondria independently of obesity and type 2 diabetes

ME de Almeida, N Ørtenblad… - The Journal of …, 2023 - Wiley Online Library
Intramuscular lipid droplets (LDs) and mitochondria are essential organelles in cellular
communication and metabolism, supporting local energy demands during muscle …