Abstract p16INK4A and p15INK4B were initially identified as potent inhibitors of activated
cyclin/cyclin-dependent kinase complexes. These genes were colocalized to chromosome …

Mounting genetic evidence suggests that each product of the Ink4a/Arf locus, p16 INK4a and
p19 ARF, possesses tumor-suppressor activity (Kamijo et al., 1997; Krimpenfort et al., 2001; …

The INK4a/ARF locus encodes two proteins involved in tumor suppression in a manner
virtually unique in mammalian cells. Distinct first exons, driven from separate promoters …

Deregulation of G1-S transition control in cell cycle is one of the important mechanisms in
the development of human tumors including astrocytic gliomas. We have previously reported …

The characterization of the molecular mechanisms involved in development and
progression of melanoma could be helpful to identify the molecular profiles underlying …

TP53 is mutated in most types of human cancers and is one of the most popular genes in
cancer research. The p53 protein is a sensor of multiple forms of genotoxic, oncogenic and …

Background: Germline mutations in the CDKN2A gene have been linked to melanoma
incidence in many families with multiple cases of the disease. Previous studies of multiple …

Cancer of the esophagus exists in 2 main forms with different etiological and pathological
characteristics—squamous cell carcinoma (SCC) and adenocarcinoma (ADC). This review …

Functional inactivation of the retinoblastoma (RB) and p53 pathways appears to be a rite of
passage for all cancerous cells and results in disruption of cell-cycle regulation and …

The p16 INK4a and p14 ARF tumor suppressor genes (TSGs) are encoded within the
CDKN2A locus on chromosome 9p21 and function as cell cycle regulatory proteins in the …