Abstract p53 and ARF-INK4a are the two most frequently altered loci in human tumors. The
activity of p53 protein is inhibited during normal cell growth by the proto-oncoprotein MDM2 …

The 9p21 gene cluster, harboring growth suppressive genes p14 ARF, p15 INK4b, and p16
INK4a, is one of the major aberration hotspots in human cancers. It was shown that p14ARF …

Head and neck carcinogenesis is believed to be a multistep process, whereby genetic
events accumulate in the carcinogen-exposed field at risk, resulting in distinct phenotypic …

Cellular senescence is a state of permanent cell-cycle arrest triggered by different internal
and external stimuli. This phenomenon is considered to be both beneficial and detrimental …

DNA methylation of tumor suppressor genes is a common feature of human cancer. The
cyclin-dependent kinase inhibitor gene p16/Ink4A is hypermethylated in a wide range of …

Abstract 1p16INK4A, a specific inhibitor of cyclin-dependent kinase (cdk) 4 and cdk6, is a
candidate tumor suppressor in malignancies with wild-type retinoblastoma (Rb). Loss of …

The methylation status of p15 INK4b (MTS2), p16 INK4a (MTS1) and p14 ARF (p16 β) was
analyzed in 56 lymphomas by restriction-enzyme related polymerase chain reaction …

Investigative interest in atypical nevi and familial melanoma has contributed to the
identification of several candidate melanoma loci within the human genome. Molecular …

Tumors often display unrestricted cell cycling attributable to a dysfunctional G1-S
checkpoint. One of the mechanisms leading to such a defect is the inactivation of the cyclin …

The CDKN2A gene maps to chromosome 9p21–22 and is responsible for melanoma
susceptibility in some families. Its product, p16, binds specifically to CDK4 and CDK6 in vitro …