Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53
has widened to include the sensing of much more diverse forms of stress, including hypoxia …

The INK4a/ARF locus encodes the cyclin dependent kinase inhibitor, p16 INK4a and the
p53 activator, p14ARF. These two proteins have an independent first exon (exon 1α and …

Frequent deletions or mutations of the INK4 gene, which encodes the cyclin-dependent
kinase 4 inhibitor p16INK4a, have been documented in various human cancers, but little is …

The cyclin-dependent kinase inhibitor p16 (p16 INK4A/CDKN2/MTS1) is a potent inhibitor of
the cyclin D-dependent phosphorylation of the retinoblastoma gene (Rb) product, the …

We have conducted an analysis of genetic alterations in spontaneous murine melanoma cell
line B16F 0 and its two metastatic clones, B16F 1 and B16F 10 and the carcinogen-induced …

Xeroderma pigmentosum (XP), a rare hereditary syndrome, is characterized by a
hypersensitivity to solar irradiation due to a defect in nucleotide excision repair resulting in a …

The INK4a/ARF locus on human chromosome 9p resides at the nexus of two critical cell
cycle regulatory pathways, the p53 pathway and the retinoblastoma (pRb) gene pathway …

Abstract P16 and P14ARF are two tumor suppressors encoded by the locus ink4a-arf which
is frequently deleted in human tumors. Recent experiments performed with mouse …

As the molecular events responsible for astrocytoma formation and progression are being
clarified, it is becoming possible to correlate these alterations with the specific …

Genetic lesions found in tumors are often targeted to the negative growth regulatory tumor
suppressor genes. Much of our understanding of tumor suppressor gene function is derived …