Genotoxic and non-genotoxic pathways of p53 induction
O Pluquet, P Hainaut - Cancer letters, 2001 - Elsevier
Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53
has widened to include the sensing of much more diverse forms of stress, including hypoxia …
has widened to include the sensing of much more diverse forms of stress, including hypoxia …
A melanoma-associated germline mutation in exon 1β inactivates p14ARF
The INK4a/ARF locus encodes the cyclin dependent kinase inhibitor, p16 INK4a and the
p53 activator, p14ARF. These two proteins have an independent first exon (exon 1α and …
p53 activator, p14ARF. These two proteins have an independent first exon (exon 1α and …
INK4a Gene Expression and Methylation in Primary Breast Cancer: Overexpression of p16INK4a Messenger RNA Is a Marker of Poor Prognosis
R Hui, RD Macmillan, FS Kenny, EA Musgrove… - Clinical cancer …, 2000 - AACR
Frequent deletions or mutations of the INK4 gene, which encodes the cyclin-dependent
kinase 4 inhibitor p16INK4a, have been documented in various human cancers, but little is …
kinase 4 inhibitor p16INK4a, have been documented in various human cancers, but little is …
Mechanisms of p16INK4A inactivation in non small-cell lung cancers
S Gazzeri, V Gouyer, C Vour'Ch, C Brambilla… - Oncogene, 1998 - nature.com
The cyclin-dependent kinase inhibitor p16 (p16 INK4A/CDKN2/MTS1) is a potent inhibitor of
the cyclin D-dependent phosphorylation of the retinoblastoma gene (Rb) product, the …
the cyclin D-dependent phosphorylation of the retinoblastoma gene (Rb) product, the …
Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines
VO Melnikova, SV Bolshakov, C Walker… - Oncogene, 2004 - nature.com
We have conducted an analysis of genetic alterations in spontaneous murine melanoma cell
line B16F 0 and its two metastatic clones, B16F 1 and B16F 10 and the carcinogen-induced …
line B16F 0 and its two metastatic clones, B16F 1 and B16F 10 and the carcinogen-induced …
The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors
L Daya-Grosjean, A Sarasin - Mutation Research/Fundamental and …, 2005 - Elsevier
Xeroderma pigmentosum (XP), a rare hereditary syndrome, is characterized by a
hypersensitivity to solar irradiation due to a defect in nucleotide excision repair resulting in a …
hypersensitivity to solar irradiation due to a defect in nucleotide excision repair resulting in a …
Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus
KD Robertson, PA Jones - Oncogene, 1999 - nature.com
The INK4a/ARF locus on human chromosome 9p resides at the nexus of two critical cell
cycle regulatory pathways, the p53 pathway and the retinoblastoma (pRb) gene pathway …
cycle regulatory pathways, the p53 pathway and the retinoblastoma (pRb) gene pathway …
p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma
G Fulci, M Labuhn, D Maier, Y Lachat, O Hausmann… - Oncogene, 2000 - nature.com
Abstract P16 and P14ARF are two tumor suppressors encoded by the locus ink4a-arf which
is frequently deleted in human tumors. Recent experiments performed with mouse …
is frequently deleted in human tumors. Recent experiments performed with mouse …
A molecular genetic model of astrocytoma histopathology
DN Louis - Brain pathology, 1997 - Wiley Online Library
As the molecular events responsible for astrocytoma formation and progression are being
clarified, it is becoming possible to correlate these alterations with the specific …
clarified, it is becoming possible to correlate these alterations with the specific …
Mouse models in tumor suppression
N Ghebranious, LA Donehower - Oncogene, 1998 - nature.com
Genetic lesions found in tumors are often targeted to the negative growth regulatory tumor
suppressor genes. Much of our understanding of tumor suppressor gene function is derived …
suppressor genes. Much of our understanding of tumor suppressor gene function is derived …