Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

Intersectins (ITSNs) are a family of multi-domain proteins involved in regulation of diverse
cellular pathways. These scaffold proteins are well known for regulating endocytosis but …

Background Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality
rate. Little is known about its invasion and metastasis mechanism so far. Methods To identify …

Cockayne Syndrome (CS) is a rare neurodegenerative disease characterized by short
stature, accelerated aging and short lifespan. Mutations in two human genes, ERCC8/CSA …

Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular
domains, each with distinct ligand preferences. Although ITSNs were initially implicated in …

Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate
endocytosis and cell signaling. ITSN genes are highly conserved and present in all …

Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions
including regulation of endocytosis, vesicle transport, and activation of various signal …

Endocytosis is a cellular process mostly responsible for membrane receptor internalization.
Cell membrane receptors bind to their ligands and form a complex which can be …

Spry2 is a molecular modulator of tyrosine kinase receptor signaling pathways that has
cancer-type-specific effects. Mammalian Spry2 protein undergoes tyrosine and serine …

T‐cell receptor (TCR) ligation‐mediated protein phosphorylation regulates the activation,
cellular responses, and fates of T cells. Here, we used time‐resolved high‐resolution …