Angiotensin II receptor blockers (ARBs) represent a new class of effective and well tolerated
orally active antihypertensive agents. Recent clinical trials have shown the added benefits of …

Their amino acid sequence seems to be highly conserved across species and across
tissues within a species. AT1 and AT2 receptors share only 34% homology and have distinct …

Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists. In
landmark clinical trials, pharmacological inhibition of the renin-angiotensin system (RAS) …

Synopsis Valsartan competitively and selectively inhibits the actions of angiotensin II at the
AT 1 receptor subtype which is responsible for most of the known effects of angiotensin II. In …

BACKGROUND:: Patients with hypertension may require combination therapy to attain the
blood pressure targets recommended by US and European treatment guidelines …

Background ACE inhibitors are widely prescribed for hypertension so it is essential to
determine and compare their effects on blood pressure (BP), heart rate and withdrawals due …

Considerable evidence now suggests that the precursors and enzymes necessary for the
formation and degradation of biologically active forms of angiotensins are present in brain …

We compared the antihypertensive efficacy of available drugs in the new angiotensin-II-
antagonist (AIIA) class. The antihypertensive efficacy of losartan, valsartan, irbesartan, and …

Background Angiotensin receptor blockers (ARBs) are widely prescribed for hypertension so
it is essential to determine and compare their effects on blood pressure (BP), heart rate and …

Background Survivors of acute myocardial infarction (MI) complicated by heart failure and/or
resulting in left ventricular dysfunction are at heightened risk for subsequent death and …