Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …

Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of
neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses …

The amyloid cascade hypothesis, focusing on pathological proteins aggregation, has so far
failed to uncover the root cause of Alzheimer's disease (AD), or to provide an effective …

Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and
neurogenesis, exists throughout the normal lifespan but declines with age and is …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

The cellular and molecular distinction between brain aging and neurodegenerative disease
begins to blur in the oldest old. Approximately 15–25% of observations in humans do not fit …

Alzheimer disease (AD) is a chronic disease characterized by a progressive decline in
memory and cognition. AD progression is closely correlated with neuropathologic changes …

Alzheimer's disease (AD) is a pressing global issue, demanding effective diagnostic
approaches. This systematic review surveys the recent literature (2018 onwards) to …

The amyotrophic lateral sclerosis–parkinsonism dementia complex (ALS-PDC) of Guam is
an endemic neurodegenerative disease that features widespread tau tangles, occasional α …