Cardiovascular disease (CVD) is the most prominent cause of death of adults in the United
States with coronary artery disease being the most common type of CVD. Following a …

Cardiomyopathies are associated with fibrotic remodeling of the heart, which is
characterized by the excessive accumulation of collagen type I (COL I) due to chronic …

Endothelial dysfunction is an early event in coronary microvascular disease. Integrin-linked
kinase (ILK) prevents endothelial nitric oxide synthase (eNOS) uncoupling and, thus …

Myocardial infarction (MI) is a dramatic event often caused by atherosclerotic plaque erosion
or rupture and subsequent thrombotic occlusion of a coronary vessel. The low supply of …

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely
prescribed due to the enhanced therapeutic profiles resulting from the synergistic …

Cardiac fibrosis is a significant global health problem associated with almost all types of
heart disease. Extensive cardiac fibrosis reduces tissue compliance and contributes to …

In infarcted and failing hearts, TGF-β superfamily members play an important role in
regulation of inflammatory, reparative, fibrogenic, and hypertrophic responses through …

Adipose tissue is a crucial regulator in maintaining cardiovascular homeostasis by secreting
various bioactive products to mediate the physiological function of the cardiovascular …

Cardiac interstitium is a complex and dynamic environment, vital for normal cardiac structure
and function. Telocytes are active cellular players in regulating main events that feature …

This work explores the epicardial implantation of acellular chitosan hydrogels in two murine
models of cardiomyopathy, focusing on their potential to restore the functional capacity of the …