Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Stem cell therapy is an emerging treatment paradigm for stroke patients with remaining
neurological deficits. While allogeneic cell transplants overcome the manufacturing …

Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of
insulin-producing β-cells in the pancreas by cytotoxic T-cells. To date, there are no drugs …

Here we aim at providing a concise but comprehensive overview of the perspectives and
challenges of heart repair with pluripotent stem cell-derived cardiomyocytes. This Review …

Cohen syndrome is an autosomal recessive disorder caused by VPS13B (COH1) gene
mutations. This syndrome is significantly underdiagnosed and is characterized by …

Induced pluripotent stem cells (iPSCs), capable of differentiating into any cell type, are a
promising tool for solving the problem of donor organ shortage. In addition, reprogramming …

Primary human cells cultured in 3D organoid format have great promise as potential
regenerative cellular therapies, but their immunogenicity has not yet been fully …

Biology of pluripotency is a modern field of biological science, and at the same time a tool for
modeling human morphogenesis in vitro. Pluripotency is the property of cells to self-renew …

The iPSCs (hereinafter, iPS) were cultured as previously reported [14]. The B2M knockout
iPS cell line (iPS_dB2M) was obtained earlier [15]. iPSC differentiation into chondrocyte-like …

Funding: chondrocyte-like cells were obtained from iPSCs within the framework of the State
Assignment# 122032300191-2 “Organoid-22”. Immunocytochemical and PCR-based …