An overview of quinazolines: Pharmacological significance and recent developments

V Alagarsamy, K Chitra, G Saravanan… - European journal of …, 2018 - Elsevier
Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or groupings divulges privileged specificities in …

Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review

Z Haghighijoo, L Zamani, F Moosavi… - European journal of …, 2022 - Elsevier
Quinazolines are considered as a promising class of bioactive heterocyclic compounds with
broad properties. Particularly, the quinazoline scaffold has an impressive role in the design …

Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders

M Leopoldo, E Lacivita, F Berardi, R Perrone… - Pharmacology & …, 2011 - Elsevier
Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the
central nervous system, serotonin (5-HT) has been shown to be involved in virtually all …

Medicinal perspective of quinazolinone derivatives: Recent developments and structure–activity relationship studies

SK Wahan, B Sharma… - Journal of Heterocyclic …, 2022 - Wiley Online Library
Heterocyclic rings have long piqued the interest of medicinal chemists. Quinazolinone is a
fused nitrogen‐based heterocyclic moiety. Some of quinazolinone derivatives have …

Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy

O Mnie-Filali, C Faure, L Lambás-Señas… - …, 2011 - nature.com
Current antidepressants still display unsatisfactory efficacy and a delayed onset of
therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT 7) …

Preparation of 2, 3-dihydroquinazolin-4 (1 H)-one derivatives in aqueous media with β-cyclodextrin-SO 3 H as a recyclable catalyst

J Wu, X Du, J Ma, Y Zhang, Q Shi, L Luo, B Song… - Green …, 2014 - pubs.rsc.org
A new β-cyclodextrin-SO3H-assisted, convenient and efficient strategy for the preparation of
2, 3-dihydroquinazolin-4 (1H)-one derivatives in aqueous media is described. The catalyst …

Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

H Georgey, N Abdel-Gawad, S Abbas - Molecules, 2008 - mdpi.com
A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4 (3 H)-one derivatives
have been synthesized. Their structures have been elucidated on the basis of elemental …

Brønsted-Lewis dual acid sites in a chromium-based metal-organic framework for cooperative catalysis: Highly efficient synthesis of quinazolin-(4H)-1-one derivatives

S Oudi, AR Oveisi, S Daliran, M Khajeh… - Journal of colloid and …, 2020 - Elsevier
Abstract A novel MIL-101 (Cr)(MIL, Matérial Institut Lavoisier) supported propyl carboxylic
acid, denoted here as MIL-101 (Cr)-NH-CO-Pr-COOH, has been fabricated by post-synthetic …

Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones

HR Shaterian, AR Oveisi… - Synthetic Communications …, 2010 - Taylor & Francis
An efficient, inexpensive, and heterogeneous catalyst,[Al (H2PO4) 3], was applied in a three-
component, one-pot cyclocondensation reaction of isatoic anhydride with primary amines (or …

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure

D Möller, A Banerjee, TC Uzuneser… - Journal of Medicinal …, 2017 - ACS Publications
1, 4-Disubstituted aromatic piperazines are privileged structural motifs recognized by
aminergic G protein-coupled receptors. Connection of a lipophilic moiety to the …