Developing HME-based drug products using emerging science: a fast-track roadmap from concept to clinical batch
This paper presents a rational workflow for developing enabling formulations, such as
amorphous solid dispersions, via hot-melt extrusion in less than a year. First, our approach …
amorphous solid dispersions, via hot-melt extrusion in less than a year. First, our approach …
[HTML][HTML] The shelf life of ASDs: 2. Predicting the shelf life at storage conditions
F Wolbert, C Luebbert, G Sadowski - International journal of pharmaceutics …, 2023 - Elsevier
Amorphous solid dispersions (ASDs) are a widely used formulation technology for poorly
water-soluble active pharmaceutical ingredients (API). Depending on the API-polymer …
water-soluble active pharmaceutical ingredients (API). Depending on the API-polymer …
[HTML][HTML] Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions
S Dohrn, C Luebbert, K Lehmkemper… - European Journal of …, 2021 - Elsevier
Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …
their successful approval for market. ASD stability does not only depend on the interplay …
[HTML][HTML] Phase behavior of ASDs based on hydroxypropyl cellulose
C Luebbert, E Stoyanov, G Sadowski - International journal of …, 2021 - Elsevier
Novel polymeric carriers for amorphous solid dispersions (ASDs) are highly demanded in
pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates …
pharmaceutical industry to improve the bioavailability of poorly-soluble drug candidates …
Drug release from surfactant-containing amorphous solid dispersions: mechanism and role of surfactant in release enhancement
Purpose To understand how surfactants affect drug release from ternary amorphous solid
dispersions (ASDs), and to investigate different mechanisms of release enhancement …
dispersions (ASDs), and to investigate different mechanisms of release enhancement …
Water sorption in rubbery and glassy polymers, nifedipine, and their ASDs
B Gronniger, E Fritschka, I Fahrig, A Danzer… - Molecular …, 2023 - ACS Publications
Polymers like poly (vinylpyrrolidone-co-vinyl acetate)(PVPVA) or hydroxypropyl
methylcellulose acetate succinate (HPMCAS) are commonly used as a matrix for amorphous …
methylcellulose acetate succinate (HPMCAS) are commonly used as a matrix for amorphous …
The shelf life of ASDs: 1. Measuring the crystallization kinetics at humid conditions
F Wolbert, K Nikoleit, M Steinbrink… - Molecular …, 2022 - ACS Publications
Amorphous solid dispersions (ASDs), where an active pharmaceutical ingredient (API) is
dissolved in a polymer, are a favored formulation technique to achieve sufficient …
dissolved in a polymer, are a favored formulation technique to achieve sufficient …
The investigation of Flory–Huggins interaction parameters for amorphous solid dispersion across the entire temperature and composition range
Amorphous solid dispersion (ASD) is one of the most promising enabling formulations
featuring significant water solubility and bioavailability enhancements for biopharmaceutical …
featuring significant water solubility and bioavailability enhancements for biopharmaceutical …
Thermodynamic modeling of the amorphous solid dispersion-water interfacial layer and its impact on the release mechanism
S Dohrn, SO Kyeremateng, E Bochmann, E Sobich… - Pharmaceutics, 2023 - mdpi.com
During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …
Selecting excipients forming therapeutic deep eutectic systems—a mechanistic approach
F Wolbert, C Brandenbusch… - Molecular …, 2019 - ACS Publications
The majority of all newly identified active pharmaceutical ingredients (APIs) have a low
solubility in water (partly smaller than marble). In order to enhance their solubility and …
solubility in water (partly smaller than marble). In order to enhance their solubility and …